Cards for Insight: Claustrum
In a network, room for understanding.
Cards for Insight
Pick two cards, add your thoughts between.
In a network, claustroom for understanding.
One of the simplest yet most profound ways of re-aligning
your own claustrum is to zoom in and out a few times. Do.
Card: Zoom
You need to imagine the claustrum as being part of your brain.
And, imagine the brain as being part of your body.
And, your body as being part of a thin veneer biosphere, on a planet named Gaia.
And, Gaia being a small bluegreen dot in the vast expanse of the Universe.
And, the universe being part of …
.
… pick two cards and add your thoughts between …
.
Card: Understanding
What if understanding is our
ability to hold space for the
possibility of knowledge, as
it emerges, unfolds, directs
and discloses its relevance
to unexplored aspects of
things known?
.
… pick two cards and add your thoughts between …
.
Card: Claustrum
Synchrony between
cortical states.
.
… pick two cards and add your thoughts between …
.
A role for the claustrum in cognitive control
— Maxwell B. Madden, Brent W. Stewart, Michael G. White, Samuel R. Krimmel, Houman Qadir, Frederick S. Barrett, David A. Seminowicz, Brian N. Mathur
“…the claustrum receives network initiation signals from frontal cortex and, through its common projections out to many cortical areas, the claustrum dynamically instantiates cortical networks required for optimal cognitive performance.”
The claustrum coordinates cortical slow-wave activity
— Kimiya Narikiyo, Rumiko Mizuguchi, Ayako Ajima, Momoko Shiozaki, Hiroki Hamanaka, Joshua P Johansen, Kensaku Mori, Yoshihiro Yoshihara
During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity. Here, we report that the claustrum coordinates neocortical SW generation. We established a transgenic mouse line that enabled the genetic interrogation of a subpopulation of claustral glutamatergic neurons. These neurons received inputs from and sent outputs to widespread neocortical areas. The claustral neuronal firings mostly correlated with cortical SW activity. In vitro optogenetic stimulation of the claustrum induced excitatory postsynaptic responses in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons. In vivo optogenetic stimulation induced a synchronized down-state featuring prolonged silencing of neural activity in all layers of many cortical areas, followed by a down-to-up state transition. In contrast, genetic ablation of claustral neurons attenuated SW activity in the frontal cortex. These results demonstrate a crucial role of claustral neurons in synchronizing inhibitory interneurons across wide cortical areas for the spatiotemporal coordination of SW activity.
Search query: claustrum
